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61.
Yasuha Watanabe Prof. Kenzo Fujimoto 《Chembiochem : a European journal of chemical biology》2020,21(22):3244-3248
The regulation of DNAzyme activity is an important problem for its in vivo applications. We achieved photochemical regulation of DNAzyme activity by using reversible DNA photo-crosslinking of 3-cyanovinylcarbazole (CNVK). The ODN containing CNVK photo-crosslinked to a pyrimidine base in the complementary strand after a few seconds of photoirradiation, and its photoadduct was split by photoirradiation of another wavelength. The activity of photo-crosslinked DNAzyme with CNVK was completely inhibited (OFF state). In contrast, after 312 nm irradiation, DNAzyme activity was recovered upon addition of a substrate strand (ON state). In addition, the photo-crosslinked DNAzyme is prone to enzymatic digestion by exonuclease. This photochemical OFF to ON switching with reversible DNA photo-crosslinking was regulated at the desired time and position; therefore, it might be possible to use it for in vivo application. 相似文献
62.
采用氟盐法制备了TiB2质量分数为3%的原位合成TiB2/6061复合材料,研究了固溶温度和固溶时间对复合材料硬度和耐磨性能的影响。结果表明:TiB2颗粒弥散分布在6061铝合金基体中,明显细化6061铝合金基体晶粒。当固溶温度一定时,随固溶时间延长,复合材料的硬度和耐磨性可获得明显提高,但固溶时间在6~10 h时,复合材料的性能变化不显著。当固溶时间一定时,随固溶温度升高,复合材料硬度和耐磨性呈现先上升后下降的趋势。3wt%TiB2/6061复合材料经530 ℃×10 h固溶处理后,硬度和耐磨性能最佳,相较于铸态硬度值提高了79.5%,磨损量减少了59.1%。固溶处理后复合材料的磨损表面犁沟变细变浅,材料脱落现象减少。 相似文献
63.
Anh K. Lam Hannah Panlilio Jennifer Pusavat Cassandra L. Wouters Erika L. Moen Prof. Robert E. Brennan Prof. Charles V. Rice 《ChemMedChem》2020,15(15):1421-1428
Infections from antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa are a serious threat because reduced antibiotic efficacy complicates treatment decisions and prolongs the disease state in many patients. To expand the arsenal of treatments against antimicrobial-resistant (AMR) pathogens, 600-Da branched polyethylenimine (BPEI) can overcome antibiotic resistance mechanisms and potentiate β-lactam antibiotics against Gram-positive bacteria. BPEI binds cell-wall teichoic acids and disables resistance factors from penicillin binding proteins PBP2a and PBP4. This study describes a new mechanism of action for BPEI potentiation of antibiotics generally regarded as agents effective against Gram-positive pathogens but not Gram-negative bacteria. 600-Da BPEI is able to reduce the barriers to drug influx and facilitate the uptake of a non-β-lactam co-drug, erythromycin, which targets the intracellular machinery. Also, BPEI can suppress production of the cytokine interleukin IL-8 by human epithelial keratinocytes. This enables BPEI to function as a broad-spectrum antibiotic potentiator, and expands the opportunities to improve drug design, antibiotic development, and therapeutic approaches against pathogenic bacteria, especially for wound care. 相似文献
64.
南厂铅锌矿位于兰坪—思茅中生代坳陷北端,构造格局复杂,成矿条件优越。通过对矿床进行野外地质调查,对成矿地质背景、矿床地质特征、成矿机制和矿床成因进行了分析,发现南厂铅锌矿体主要呈透镜状赋存于第三系云龙组(Eyb)及下白垩统景星组(K1j1)地层中,与围岩接触部位发育微弱褪色蚀变,云龙组下段(Eya)是矿体底板有效的“屏蔽层”;区内发育原生砂岩型矿石、灰岩型矿石和氧化矿石,沉积构造特征明显,局部具有热液、变质作用改造特征;矿区地层、构造是矿床形成的重要因素,断裂构造是主要的容矿、导矿构造,高盐度热卤水沿导矿构造循环至有利层位、构造部位富集成矿,综合分析认为南厂矿床属热卤水为主的多成因层控型铅锌矿床。 相似文献
65.
腾冲市茨竹地铁多金属矿现目前是一座正在开采的以磁铁矿为主、共(伴)生锡钨矿的小型矿山。为了增加矿山资源储量、延长矿山服务年限,通过对矿区的地质特征阐述和对矿区地层岩性、构造、岩体等控矿因素的分析研究,总结了矿区成矿规律并形成了矿区的成矿模式,为矿区深部探矿、外围找矿提供了一定的理论依据。 相似文献
66.
Siddhartha Sankar Mandal K. S. Ghosh 《International Journal of Cast Metals Research》2018,31(3):177-192
Destabilisation of as-cast chromium white iron with 16 wt-% chromium are performed by continuous destabilisation treatment for 4 h and short duration (0.66 h) cyclic destabilisation treatment at 900, 950, 1000, 1050, and 1100 °C. Continuous destabilisation causes secondary carbides precipitation from austenite which on slow cooling transforms to pearlite matrix. Cyclic destabilisation treatment causes similar precipitation of finer secondary carbides following shorter period austenitisation and a matrix containing martensite and retained austenite on forced-air cooling. After continuous destabilisation, hardness falls below the as-cast value (HV622); whereas it rises to HV950 after cyclic destabilisation treatment. The as-cast notched impact toughness (4.0 J) increases to 8.5 J or more after both continuous and cyclic destabilisation at 1050 and 1100 °C. Abrasive wear resistance after continuous destabilisation improves only at higher wear load (49.0 N), while after cyclic destabilisation it supersedes the as-cast and Ni-Hard IV performance at both low (19.6 N) and high (49.9 N) wear load. 相似文献
67.
68.
69.
Yongsen Wei 《Energy Sources, Part A: Recovery, Utilization, and Environmental Effects》2018,40(24):3009-3018
Heat transfer has considerable applications in different industries such as designing of heat exchanger, nuclear reactor cooling, control system for spacecraft, and designing of microelectronics cooling. As the surfaces of two metals contact each other, this issue becomes so crucial. Thermal contact resistance (TCR) is one of the key physical parameters in heat transfer of mentioned surfaces. Measuring the experimental value of TCR in laboratory is highly expensive and difficult. As an alternative, numerical modeling methods could be engaged. In this study, inverse problem method solution is utilized as a proper method for estimation of TCR value. In this order, three different configurations (flat-flat, flat-cylinder, and cylinder-cylinder) were utilized in two steady and unsteady state conditions to predict the value of TCR. A comparison between the measured values and obtained values from the simulation show the errors for flat-flat, flat-cylinder, and cylinder-cylinder configuration after 10 min from starting the experiment are 4.6074%, 0.1662%, and 0.5622%, respectively. And in steady-state condition, the corresponding errors are 6.06e-3%, 1.506%, and 0.846%, respectively. In conclusion, the final results establish the fact that the inverse problem method solution can predict TCR values between contacting surfaces. 相似文献
70.